{"id":10371,"identifier":"DVN/FBWPVH","persistentUrl":"http://doi.org/10.18170/DVN/FBWPVH","protocol":"doi","authority":"10.18170","publisher":"Peking University Open Research Data Platform","publicationDate":"2020-06-12","storageIdentifier":"file://10.18170/DVN/FBWPVH","datasetVersion":{"id":861,"storageIdentifier":"file://10.18170/DVN/FBWPVH","versionNumber":1,"versionMinorNumber":0,"versionState":"RELEASED","productionDate":"Production Date","UNF":"UNF:6:wp2rM/xsqRSpdhQB1x1n3g==","lastUpdateTime":"2020-06-12T06:01:22Z","releaseTime":"2020-06-12T06:01:22Z","createTime":"2020-06-12T06:00:08Z","license":"CC0","termsOfUse":"CC0 Waiver","fileAccessRequest":false,"metadataBlocks":{"citation_zh":{"displayName":"引用元数据","fields":[{"typeName":"title_zh","multiple":false,"typeClass":"primitive","value":"MTHFR基因C677T多态性与利培酮治疗精神分裂症体重增加不良反应的遗传关联研究"},{"typeName":"author_zh","multiple":true,"typeClass":"compound","value":[{"authorName_zh":{"typeName":"authorName_zh","multiple":false,"typeClass":"primitive","value":"岳伟华"},"authorAffiliation_zh":{"typeName":"authorAffiliation_zh","multiple":false,"typeClass":"primitive","value":"亚洲成人在线一二三四五六区"}}]},{"typeName":"datasetContact_zh","multiple":true,"typeClass":"compound","value":[{"datasetContactName_zh":{"typeName":"datasetContactName_zh","multiple":false,"typeClass":"primitive","value":"岳伟华"},"datasetContactAffiliation_zh":{"typeName":"datasetContactAffiliation_zh","multiple":false,"typeClass":"primitive","value":"亚洲成人在线一二三四五六区"},"datasetContactEmail_zh":{"typeName":"datasetContactEmail_zh","multiple":false,"typeClass":"primitive","value":"dryue@bjmu.edu.cn"}}]},{"typeName":"depositor_zh","multiple":false,"typeClass":"primitive","value":"岳伟华"},{"typeName":"dateOfDeposit_zh","multiple":false,"typeClass":"primitive","value":"2020-06-12"},{"typeName":"dsDescription_zh","multiple":true,"typeClass":"compound","value":[{"dsDescriptionValue_zh":{"typeName":"dsDescriptionValue_zh","multiple":false,"typeClass":"primitive","value":"为探索MTHFR基因C677T多态性与利培酮治疗精神分裂症所致体重增加不良反应的关联，我们在356例精神分裂症患者中进行了药物遗传学关联分析。结果发现MTHFR C677T多态性位点的C等位基因携带者较TT基因型携带者的体重指数(BMI)在利培酮治疗8周时显著增加。"}}]},{"typeName":"subject_zh","multiple":true,"typeClass":"controlledVocabulary","value":["医药、健康与生命科学"]}]},"citation":{"displayName":"Citation Metadata","fields":[{"typeName":"title","multiple":false,"typeClass":"primitive","value":"C677T polymorphism in the MTHFR gene is associated with risperidone-induced weight gain in schizophrenia"},{"typeName":"author","multiple":true,"typeClass":"compound","value":[{"authorName":{"typeName":"authorName","multiple":false,"typeClass":"primitive","value":"Weihua Yue"},"authorAffiliation":{"typeName":"authorAffiliation","multiple":false,"typeClass":"primitive","value":"Peking University Sixth Hospital, Institute of Mental Health, Beijing, China"}}]},{"typeName":"datasetContact","multiple":true,"typeClass":"compound","value":[{"datasetContactName":{"typeName":"datasetContactName","multiple":false,"typeClass":"primitive","value":"Weihua Yue"},"datasetContactAffiliation":{"typeName":"datasetContactAffiliation","multiple":false,"typeClass":"primitive","value":"Peking University Sixth Hospital, Institute of Mental Health, Beijing, China"},"datasetContactEmail":{"typeName":"datasetContactEmail","multiple":false,"typeClass":"primitive","value":"dryue@bjmu.edu.cn"}}]},{"typeName":"dateOfDeposit","multiple":false,"typeClass":"primitive","value":"2020-06-12"},{"typeName":"dsDescription","multiple":true,"typeClass":"compound","value":[{"dsDescriptionValue":{"typeName":"dsDescriptionValue","multiple":false,"typeClass":"primitive","value":"To explore the association of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism with risperidone-induced weight gain. We analyzed the association between MTHFR C677T polymorphism and risperidone-induced weight gain in 356 schizophrenia patients. We found a significant association between MTHFR C677T polymorphism and body mass index (BMI) change after 8-week treatment with risperidone. After 8- week treatment with risperidone, increased BMI values (kg/m2) of MTHFR C677 carriers was significantly higher than that of TT genotype carriers"}}]},{"typeName":"subject","multiple":true,"typeClass":"controlledVocabulary","value":["Medicine, Health and Life Sciences"]}]}},"files":[{"label":"MTHFR C677T-20200602提交版2.txt.tab","restricted":false,"version":2,"datasetVersionId":861,"dataFile":{"id":10372,"persistentId":"","pidURL":"","filename":"MTHFR C677T-20200602提交版2.txt.tab","contentType":"text/tab-separated-values","filesize":6408,"storageIdentifier":"172a71cfa6b-fa844a1bdc18","originalFileFormat":"application/vnd.openxmlformats-officedocument.spreadsheetml.sheet","originalFormatLabel":"MS Excel (XLSX)","originalFileSize":15911,"UNF":"UNF:6:wp2rM/xsqRSpdhQB1x1n3g==","rootDataFileId":-1,"md5":"0af37a582b3e8004b4ac775030abaf85","checksum":{"type":"MD5","value":"0af37a582b3e8004b4ac775030abaf85"},"creationDate":"2020-06-12"}}],"citation":"Weihua Yue, 2020, \"C677T polymorphism in the MTHFR gene is associated with risperidone-induced weight gain in schizophrenia\", http://doi.org/10.18170/DVN/FBWPVH, Peking University Open Research Data Platform, V1, UNF:6:wp2rM/xsqRSpdhQB1x1n3g== [fileUNF]"}}